A mathematical model of the human menstrual cycle.

نویسندگان

  • W J Shack
  • P Y Tam
  • T J Lardner
چکیده

A mathematical model for the hormonal interactions of the human menstrual cycle is presented. The feedback effects of estrogen on the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are considered, including a mechanism describing the midcycle LH peak. Computer simulation with this model yields results which are periodic and in good agreement with physiological data.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Focal Adhesion Kinase (FAK) Involvement in Human Endometrial Remodeling During the Menstrual Cycle

Background: Endometrial remodeling occurs during each menstrual cycle in women. Reports have shown that, in a variety of cell types, processes such as proliferation, signaling complex formation and extra cellular matrix remodeling require a cytoplasmic tyrosine kinase, focal adhesion kinase (FAK). The present study has focused on the expression pattern of FAK in human endometrium during the men...

متن کامل

Mathematical Model for Emergent Oscillations in Human Menstrual Cycle Due to Constant and Progressive Human Stress

The Aim of this study is to develop a mathematical model of the hypothalamopituitary-gonadal axis that would reflect available data in humans. A model of hormonal relationships at the early follicular and midluteal phases of the human menstrual cycle is proposed. Further development of models of the endocrine system may lead to better understanding of the relationship between mental illness, ph...

متن کامل

P-142: Adenosine Deaminase Activity during Menses, Follicular and Luteal Phases of Menstrual Cycle

Background: In recent years, numerous regulators of gonadal function have been studied. Adenosine deaminase(ADA) is widely distributed throughout human tissues and may contribute in the regulation of menstrual cycle. The purpose of this study was to determine the plasma activities of total adenosine deaminase (ADAT), and its isoenzymes, ADA1 and ADA2, and ADA1/ADA2 ratio during the menses, foll...

متن کامل

A mathematical model for the human menstrual cycle

A simple mathematical model framework is developed to describe the hormonal interactions of the human menstrual cycle along the hypothalamus-pituitary-ovaries axis. The framework is designed so that it can be readily extended to model processes that disrupt the normal functioning cycle. The model in its most basic formulation exhibits multiple periodic solutions, one of which shows the key char...

متن کامل

O-31: Epigenetic Aberration of HOXA10 Gene in Human Endometrium throughout The Menstrual Cycle in Endometriosis

Background: Epigenetic aberration such as DNA methylation and histone modifications appear to be involved in various diseases such as Endometriosis. Here, we investigated the epigenetic regulation of HOXA10 promoter, as a crucial gene, responsible for uterine organogenesis, functional endometrial differentiation and endometrial receptivity, and its correlation with mRNA expression of this gene ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Mathematical medicine and biology : a journal of the IMA

دوره 31 1  شماره 

صفحات  -

تاریخ انتشار 1971